Saxenda works like glucagon-like-peptide (GLP-1), an appetite hormone your body naturally produces that helps to regulate your hunger. This can lead to eating fewer calories and weight loss. And there’s more good news: Saxenda is not a stimulant. Our bodies naturally produce appetite hormone glucagon-like-peptide (GLP-1) that helps regulate hunger, Saxenda works by bonding with GLP-1 receptors and in turn regulates appetite by increasing feelings of fullness and satiety, lowering feelings of hunger (1,2). Simply put you feel full for much longer – which in turn can result in eating less calories and losing weight. Prescription weight-loss drugs work best when used along with — and not in place of — lifestyle changes.
Saxenda (liraglutide) is a prescription drug approved in the United States for spurring and maintaining weight loss when added to calorie-cutting and exercise. Liraglutide is sold under two brand-names: Saxenda, the weight loss drug, and Victoza, for type 2 diabetes. Saxenda contains a higher dose of liraglutide and works by mimicking the action of an appetite hormone called GLP-1, according to the drug’s maker, Novo Nordisk. This has been shown to be effective at inducing and sustaining weight loss in a population of obese patients including those with hypertension, dyslipidemia, type 2 diabetes and obstructive sleep apnea. Discontinuation due to adverse effects (primarily gastrointestinal) is highest for liraglutide and naltrexone/bupropion and lowest for lorcaserin.
The higher rates of discontinuation for liraglutide compared with some other obesity medications due to adverse effects may limit its use in some patient populations. Also, liraglutide is an injectable medication with a high monthly cost. However, it offers the unique benefit of improved glycemic control and its relatively few contraindications as compared with other weight loss agents make it an attractive option for patients, especially with comorbid type 2 diabetes or cardiovascular disease. Additional studies are needed to determine its long-term outcomes, including its effects on cardiovascular morbidity and mortality, in a large and diverse population with varying races/ethnicities, for a weight loss indication.
Definitely, liraglutide remains another important option in the physician’s toolkit to combat the growing obesity epidemic in the United States. Saxenda prescription medicine used for adults with obesity to help them lose weight and keep the weight off. Saxenda should be used with a reduced calorie diet and increased physical activity. When choosing a weight loss prescription or program it can be tempting to focus on achieving the initial weight loss, however it is also important to look at what you want to achieve and what you can sustain and afford in the long term especially if the Saxenda are very expensive in the USA. While exercise is a portion of living a healthy active lifestyle, what you eat is an even larger factor.
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