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Humalog and Novolog : What’s The Difference?

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Millions of Americans with diabetes use insulin regularly, whether it’s for Type 1 diabetes, Type 2 diabetes, or gestational diabetes. Insulins like Humalog and Novolog are necessary to regulate blood sugar levels in those with diabetes. But what’s the difference between these insulin products?

Diabetes is not a curable condition, but it can be managed with treatment and lifestyle changes. According to the Centers for Disease Control and Prevention (CDC), normal fasting blood sugar is under 99 mg/dL, whereas fasting diabetic blood sugar level is higher than 126 mg/dL. It is important to regularly screen blood glucose levels during check-ups with your doctor to monitor whether you are at risk for diabetes. Type 1 diabetes is usually diagnosed early during youth so it is also called juvenile diabetes. Type 2 diabetes can be diagnosed at any age, although it is more common in adults. A blood sugar level between 100-125 mg/dL can indicate prediabetes, and with certain lifestyle changes it can be prevented from developing into type 2 diabetes. Since in both type 1 and 2 diabetes the body cannot make insulin itself, diabetic patients have to take artificial insulin for the rest of their lives. Most of the time, diabetic patients are given one type of insulin that works throughout the day, and another insulin that can process quick rises in blood sugar levels after eating. Insulin is injected under your skin into the fat. It’s the most common type of treatment for type 1 diabetes because it works quickly. Humalog and Novolog are both equivalent to the insulin made in your body. Unlike oral diabetes drugs, insulin provides fast relief for changes in your blood sugar. The type of insulin your doctor prescribes depends on how often and how much your blood sugar fluctuates each day.

Difference Between Humalog and Novolog

Activation Time

Both drugs are fast acting insulin. However, Novolog starts to work a little faster than Humalog after injection. Novolog starts about 5 to 10 minutes after injection, whereas Humalog takes up to 15 minutes to start working. Therefore, it is recommended that Novolog is administered 5 to 10 minutes before eating a meal or soon after you start eating a meal, and Humalog is best administered 15 minutes before a meal or right after the meal is finished. Both take the same amount of time to reach their peak concentration (1 hour) and their effects last for the same amount of time (2 to 3 hours).


Both Humalog and Novolog are recommended for adults with type 1 or type 2 diabetes. They differ in the age recommendation for children with type I diabetes. Humalog Kwikpen is recommended for children with type 1 diabetes that are above the age of 3 years, whereas Novolog can be used by children with type 1 diabetes that are 2 years of age or older.

Common Side effects

Low blood sugar is the most common side effect of Humalog or Novolog. While it’s important to lower your blood sugar levels if you have diabetes, it’s possible for your blood sugar level to get too low. You should be sure your blood sugar level doesn’t fall below 70 mg/dL. Other factors can affect your blood sugar level as well, including: your diet, exercise. habits, stress levels. This is why testing your blood sugar as often as your doctor says to is so important. Other common side effects of Humalog and Novolog include: diarrhea, headaches, nausea, weight gain. Serious side effects can also occur. These can include: reaction at the injection site, fluid retention and swelling, heart disease, low blood potassium levels, allergic reactions such as hives, itching, wheezing, difficulty breathing, or swelling in your face, fluid retention and swelling (a serious but rare occurrence).

Rapid acting

Both Humalog and Novolog are rapid-acting insulin. Research has shown that rapid acting insulin works better in controlling blood glucose levels before or after a meal. They take about 10-15 minutes to start working and peak at 1

hour after injection. The effects last for 2 to 3 hours after injection. Humalog should be injected 15 minutes before a meal, and Novolog should be injected 5 to 10 minutes before a meal.

Humalog and Novolog are both indicated for the treatment of type 1 or type 2 diabetes. Novolog is prescribed more generally for both types of diabetes, whereas Humalog insulin is more commonly prescribed for type 1 diabetes, although it is prescribed for type 2 diabetes as well. Both Humalog and Novolog are also used to treat gestational diabetes, or diabetes that occurs in pregnant women. This is an off-label use for these drugs

Overall, both Humalog and Novolog are types of fast acting insulin that work to lower blood sugar levels after eating. Research has shown that both drugs are equally effective in controlling blood sugar levels after meals and they work better than long-acting insulin for this purpose. The main difference is that Novolog works slightly faster than Humalog, but the effect of both drugs last for the same amount of time. Your doctor can help you decide which insulin is better for you by considering other types of insulin or drugs you may be taking to choose the one that is likely to be the best fit with your diabetes treatment plan.

USA Script Helpers itself is not a Pharmacy. USA Script Helpers is an established Pharmacy Partner with over 10 years of experience in the online pharmaceutical industry. In conjunction with its contracted* licensed Pharmacy department, USA Script Helpers refers its customers to its’ contracted* Pharmacy department to ensure that Americans all across the USA have access to the medications they need. Whether it be tablet medications, topical creams, patches, various insulins including (Lantus SoloStar Pens, Lantus Vials, Lantus Cartridges, Humalog, Novolog etc.).

USA Script Helpers not only retails human medications but also pet medications. USH offers a variety of medications including both brand name and generic equivalent. USA Script Helpers is committed to providing safe medications that you can truly rely on. USA Script Helpers is open 365 days a year to ensure that customers have access to the customer support that they need. Call us today at 1 (888) 646-7749 or simply place your order online. When Medicare is out, count us in.

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