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Breztri and Its Role in Managing Obstructive Pulmonary Disease

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Obstructive pulmonary disease (OPD) is a chronic respiratory condition that affects millions of people worldwide. It is characterized by the narrowing of the airways, which can lead to symptoms such as wheezing, shortness of breath, and coughing. One medication that is commonly used to manage OPD is Breztri. In this blog, we will explore the connection between OPD and Breztri, including how it works, potential side effects, and considerations for use.

Importance of Managing Obstructive Pulmonary Disease

Managing obstructive pulmonary disease (OPD) is crucial as it can significantly impact a person’s quality of life. OPD encompasses a range of chronic respiratory conditions such as chronic obstructive pulmonary disease (COPD), emphysema, chronic bronchitis, and asthma. These conditions can cause significant breathing difficulties, leading to shortness of breath, coughing, wheezing, and chest tightness.

Shot of a female doctor giving a patient a chest exam Breathe deeply for me pulmonary stock pictures, royalty-free photos & images

They can also limit a person’s physical activity, impair sleep, and lead to anxiety and depression. Proper management of OPD can help alleviate these symptoms and improve a person’s overall quality of life. It can also help reduce the risk of complications such as respiratory infections, respiratory failure, and even death.

What is Breztri?

Breztri, also known as budesonide/glycopyrrolate/formoterol fumarate, is a combination medication that is used to manage OPD. It contains three active ingredients:

  • Budesonide
  • Glycopyrrolate
  • Formoterol fumarate

Budesonide is a corticosteroid that helps to reduce inflammation in the airways. It works by inhibiting the release of inflammatory substances that can cause the airways to narrow, making it harder to breathe. This helps to decrease symptoms such as wheezing, coughing, and shortness of breath.

Glycopyrronium is an anticholinergic medication that works by relaxing the muscles around the airways. This helps to open up the airways and improve airflow, making it easier to breathe.

Formoterol fumarate is a long-acting beta2-adrenergic agonist (LABA) that helps to relax the muscles around the airways. This helps to improve breathing by opening up the airways and increasing airflow.

Together, these three ingredients work to manage the symptoms of OPD by reducing inflammation in the airways, relaxing the muscles around the airways, and increasing airflow. This can help to improve breathing and reduce symptoms such as coughing, wheezing, and shortness of breath.

Compared to other medications used to manage OPD, Breztri is unique in that it combines three different types of medication in one inhaler. This can be more convenient for patients and may be more effective than using multiple medications separately.

Additionally, the long-acting nature of the medications in Breztri means that it only needs to be taken twice a day, making it easier to manage than medications that need to be taken more frequently.

How does Breztri Work?

Breztri is used to manage symptoms in patients with OPD, including chronic obstructive pulmonary disease (COPD) and asthma. It is typically prescribed for individuals who have not achieved adequate symptom control with other medications or who have experienced frequent exacerbations of their condition.

Potential Side Effects of Breztri

Like all medications, Breztri can cause side effects. The most common side effects include:

  1. Upper respiratory tract infection
  2. Headache
  3. Back pain
  4. Cough
  5. Sore throat

Less common but more serious side effects can also occur, such as pneumonia, bronchitis, and worsening of COPD symptoms.

Administration and Dosage

Breztri is available as an inhaler and is typically prescribed for use twice daily. The recommended dosage is two inhalations of Breztri 320/18/9.6mcg, or one inhalation of Breztri 160/18/9.6mcg, twice daily. The inhaler should be primed before the first use and after a period of non-use. Patients should always follow their doctor’s instructions regarding dosing and use of the inhaler.

It is important to note that Breztri should not be used as a rescue inhaler for sudden symptoms. Patients should have a short-acting bronchodilator on hand for use in case of sudden breathing difficulties. Additionally, Breztri should not be used to treat asthma or acute bronchospasm.

The inhaler should be used regularly to ensure maximum benefit. Patients should not stop taking Breztri without consulting their doctor, as suddenly stopping the medication can cause symptoms to worsen. 

If a dose is missed, patients should take it as soon as they remember, unless it is almost time for the next dose. In that case, they should skip the missed dose and resume their regular dosing schedule.


As a combination inhaler, Breztri works by delivering three different medications that work together to open airways and reduce inflammation. This can lead to improved breathing and a reduction in symptoms for patients with OPD. 

However, like any medication, Breztri does come with potential side effects and should be used only under the guidance of a healthcare professional. Patients should always discuss the risks and benefits of Breztri with their doctor to determine if it is the right treatment option for them. With proper use and monitoring, Breztri can be an effective tool in managing OPD and improving quality of life for patients.

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