WHAT IS MIRABEGRON?
Mirabegron is a sympathomimetic beta-3 adrenergic receptor agonist used to relax the smooth muscle of the bladder in the treatment of urinary frequency and incontinence. It is unique amongst overactive bladder treatment options in that, unlike other treatments such as solifenacin and darifenacin, it lacks significant antimuscarinic activity,3 which is responsible both for the therapeutic effects of these medications and their broad range of adverse effects. Mirabegron has a comparatively favorable adverse effect profile as compared to other available treatment options, and its complementary mechanism to the antimuscarinics that came before it allows for its use alongside solifenacin in refractory cases.
Mirabegron first received FDA approval in 2012, under the brand name Myrbetriq, for the treatment of adults with overactive bladder.6 An extended-release granule formulation was subsequently granted approval in March 2021 for the treatment of pediatric patients with neurogenic detrusor overactivity.6 Mirabegron is also used in other jurisdictions across the globe, including Canada,7 the EU,8 and Japan.
USE
Mirabegron is indicated for the treatment of overactive bladder (OAB) – with symptoms of urge urinary incontinence, urgency, and urinary frequency – either alone or in combination with solifenacin.6 It is also indicated for the treatment of neurogenic detrusor overactivity (NDO) in pediatric patients 3 years of age and older and weighing 35kg or more.
WARNINGS
You should not use mirabegron if you have uncontrolled hypertension (high blood pressure).
BEFORE TAKING THIS MEDICINE
You should not use mirabegron if you are allergic to it.
Tell your doctor if you ever had:
- high blood pressure;
- a bladder obstruction;
- trouble emptying your bladder (very little urine or a weak stream of urine);
- kidney disease; or
- liver disease.
MIRABEGRON SIDE EFFECTS
If you develop hives, difficulty breathing, or swelling of your face, lips, tongue, or neck, stop using mirabegron and get emergency medical attention.
Contact your doctor if you experience any of the following symptoms:
- When you urinate, you may experience pain or a burning sensation; or
- High blood pressure can cause severe headaches, impaired vision, and pounding in your neck or ears.
The following are examples of common side effects:
- Urination that is excruciatingly unpleasant;
- elevated blood pressure;
- Sore throat, sinus ache
- constipation;
- or a headache
- dry mouth or fast heartbeats (when taken with solifenacin).
OVERDOSE
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away.
HOW TO STORAGE
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.
USA Script Helpers offers best priced* guaranteed. Although USA Script Helpers is not covered by Medicare, USA Script Helpers offers medical expense reports that you may submit to your local insurance companies. Should you be reimbursed that is separate from us. USA Script Helpers also offers best priced* guaranteed for all medications for more information simply give us a call at 1 (888) 646-7749.
