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WHAT IS MIRABEGRON?
Mirabegron is a sympathomimetic beta-3 adrenergic receptor agonist used to relax the smooth muscle of the bladder in the treatment of urinary frequency and incontinence. It is unique amongst overactive bladder treatment options in that, unlike other treatments such as solifenacin and darifenacin, it lacks significant antimuscarinic activity,3 which is responsible both for the therapeutic effects of these medications and their broad range of adverse effects. Mirabegron has a comparatively favorable adverse effect profile as compared to other available treatment options, and its complementary mechanism to the antimuscarinics that came before it allows for its use alongside solifenacin in refractory cases.
Mirabegron first received FDA approval in 2012, under the brand name Myrbetriq, for the treatment of adults with overactive bladder.6 An extended-release granule formulation was subsequently granted approval in March 2021 for the treatment of pediatric patients with neurogenic detrusor overactivity.6 Mirabegron is also used in other jurisdictions across the globe, including Canada,7 the EU,8 and Japan.
USE
Mirabegron is indicated for the treatment of overactive bladder (OAB) – with symptoms of urge urinary incontinence, urgency, and urinary frequency – either alone or in combination with solifenacin.6 It is also indicated for the treatment of neurogenic detrusor overactivity (NDO) in pediatric patients 3 years of age and older and weighing 35kg or more.
WARNINGS
You should not use mirabegron if you have uncontrolled hypertension (high blood pressure).
BEFORE TAKING THIS MEDICINE
You should not use mirabegron if you are allergic to it.
Tell your doctor if you ever had:
MIRABEGRON SIDE EFFECTS
If you develop hives, difficulty breathing, or swelling of your face, lips, tongue, or neck, stop using mirabegron and get emergency medical attention.
Contact your doctor if you experience any of the following symptoms:
The following are examples of common side effects:
OVERDOSE
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away.
HOW TO STORAGE
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.
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SHIPPING ADVISORY: Please be advised that due to Covid-19, Canada Post and USPS have both removed their shipping guarantee. Therefore, orders may take 7-10 business days to receive. Please be sure to place your order sooner rather than later. Should you not receive your medication within the quoted time please do not hesitate to give us a call at our toll free number 1-888-646-7749 to speak to a member of our customer support team. Thank you.
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We are implementing updated shipping options to ensure timely delivery. Please note the following updated shipping timelines and fees:
1-2 business days to process then 10-14 business days for shipping due to holiday season once canada post resumes. We are currently looking for alternative shipping methods. Updates will be provided once available.
To comply with shipping policies, a valid passport is required for order pickup. Driver’s licenses are not accepted as valid photo identification.
Canada Post:
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As the amount of medicine constituting a day supply depends on your doctors directions for use, different patients are permitted to order different quantities. Placing an order for more than a 3-month supply may delay your order as we will need to contact you. Contact us for assistance if your 3-month rule compliant desired quantity is not shown.