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USA Script Helpers is a proud health service provider. USA Script Helpers is happy to announce that the following various insulins offered are Canadian sourced. USA Script Helpers retails products such as: EpiPen, Humalog, Novalog, Lantus, Saxenda, Trulicity etc.
USA Script Helpers offers guaranteed best prices in the market. Understands the importance of shipping insulin medications in refrigerated containers to keep the medications cool while in transport. USA Script Helpers uses xpresspost to ship all insulin medications. As well, refrigeration is used and required when shipping to warmer states.
The pancreas is an organ that is important in digestion and blood sugar control. It produces and releases a variety of digestive hormones into the bloodstream and digestive system. It is a large, flat organ, about 6 inches in length, and is found in the upper left part of your abdomen behind your stomach. There are about three million cell clusters in your pancreas called pancreatic islets (or islets of Langerhans), which consist of four types of cells. Each type of cell releases one of four different hormones involved in the regulation of blood sugar levels:
When your blood sugar levels get too high, the pancreas secretes insulin. When your blood sugar levels get too low, the pancreas secretes glucagon.
Premixed insulin combines two types of insulin analogs together: basal insulin that helps you control your blood sugar all through the day, and bolus insulin for the control of blood sugar levels at meal times. Pre-mixed insulin is often referred to as simply a “Mix” insulin. Premixed insulins were initially developed to simplify your diabetes management and insulin dosing. Premixed insulin combines shorter and longer-acting insulins in one cartridge, pen or vial. With the proper ratio, it gives you quick coverage for a meal plus longer coverage for other times of the day. They are typically injected two or three times a day, before mealtime. While there is a variety of ratios of premixed insulin available, the ratios are not individually customized. The pre-mixed solutions come in ratios of 25/75, 30/70, 40/60 and 50/50, with the faster-acting insulin generally in lower relative amounts than the longer acting insulin analog.
Unlike much oral antidiabetic medications, insulin currently cannot be taken orally and needs to be taken as a subcutaneous (under the skin) injection. Like most proteins you eat, insulin gets reduced into tiny fragments once it reaches your stomach and intestines. When this happens, insulin’s therapeutic activity is lost. Currently, there are two main ways to administer your insulin analogs, either with an insulin pen or with a syringe.
Insulin dysfunction is the hallmark of diabetes, as it leads to abnormally high blood sugar levels that have profound effects on your quality of life. It is a chronic and often debilitating disease that can be fatal. As of 2016, 422 million people worldwide have diabetes, with type 2 diabetes making up about 90% of the cases. The World Health Organization predicts that by 2030 the number of people with diabetes will be more than double that number.
These symptoms may develop quickly over a few weeks or months for those with type 1 diabetes. Symptoms may come on more gradually and be more subtle, or even absent, in those with type 2 diabetes. If your diabetes is left untreated, more serious complications can occur, including diabetic ketoacidosis (DKA), hyperosmolar hyperglycemic state, blindness, amputation or even death. Other long-term complications may be cardiovascular disease, kidney disease, stroke, foot ulcers, and eye damage. Diabetes is characterized by high blood sugar, which can be diagnosed by any one of the following:
Currently, there is no known cure or preventive measure for Type 1 diabetes. Type 2 diabetes can be prevented to some degree by maintaining healthy body weight, getting regular physical activity, and consuming a balanced diet.
Type 1 diabetes, sometimes called insulin-dependent diabetes or juvenile diabetes, results from your pancreas’ inability to produce the required insulin for your body because of the loss or dysfunction of beta cells in your pancreas. The exact cause of type 1 diabetes remains unknown, although it is believed to involve a combination of environmental and genetic factors. The underlying mechanism of beta cell problems appears to involve an auto-immune attack. Auto-immune reactions occur when your body’s own defense system mistakenly targets its own cells and destroys them. In the case of diabetes, the immune system may target and destroy the beta cells in the pancreas. Type 1 diabetes must be managed with daily insulin injections and meal planning to lower and control blood sugar levels.
Gestational diabetes is a third type of diabetes. It is a temporary diabetic condition that occurs when pregnant women, who did not previously have a history of diabetes, suddenly develop high blood sugar levels during pregnancy. It affects between two to four percent of all pregnancies. It is caused by not having enough insulin, which can lead to insulin resistance. Some risk factors for gestational diabetes include being overweight, having gestational diabetes in previous pregnancies, having polycystic ovarian syndrome, and a family history of type 2 diabetes. Gestational diabetes increases the risk of depression, pre-eclampsia, and Caesarean section. Babies that are born to mothers who have inadequately treated their gestational diabetes are at an increased risk of having low blood sugar. This is due to the mother’s high blood sugar crossing into the baby’s bloodstream and prompting the baby’s pancreas to start producing insulin. Babies born to mothers with gestational diabetes may also become too large, and have an increased risk of jaundice. In the long-term, these children are also at a higher risk of becoming overweight and developing type 2 diabetes later in life.
An insulin analog is man-made insulin produced using recombinant DNA technology. The human insulin gene is inserted into E. coli bacteria, or into yeast, which then produces insulin for human use. This synthesized insulin is sometimes given minor structural changes to give it specific characteristics. This is how different insulin, such as NPH insulin, is made. However, once the insulin is absorbed by the body, it acts just like naturally occurring, human insulin. This technology has been used to produce two main types of insulin analogs: those that are more rapidly absorbed and act faster, and those that are released slowly and work over the course of the day. The faster-acting insulin analogs are designed to protect you against mealtime spikes and fluctuations in blood sugar levels. These are called mealtime, or bolus insulins. Insulins that have an extended duration of action are used for maintaining blood sugar levels throughout the day and night. These are called basal, or background insulins. Recombinant technology has almost completely replaced insulin produced from animals, such as pigs and cows. Before synthesized insulin, pig pancreases were used to produce usable insulin. It took two tons of pig pancreas to produce only eight ounces of purified insulin.
Basal-Bolus therapy involves combining a longer-acting, or basal insulin analog, together with separate injections of a shorter-acting, or bolus insulin analog. The role of basal insulin, also known as background insulin, is to keep blood sugar levels stable throughout the day and allow your body to take in sugar used for energy for all of the functions needed to support daily life. It acts over a relatively long period of time and is usually taken once or twice a day. Either long-acting or intermediate-acting insulin analog is used as part of basal-bolus insulin therapy. The other part of basal-bolus insulin therapy includes bolus insulin, which is specifically taken at mealtimes to prevent the blood sugar spikes your body experiences after meals. It needs to act quickly, therefore short-acting and rapid-acting insulin analogs are used in basal-bolus insulin therapy. For basal-bolus therapy, you generally take multiple daily subcutaneous injections, which better replicates the way naturally occurring human insulin works in your body. A healthy pancreas naturally releases more insulin during meals, to combat the blood sugar level spikes that occur during and after mealtime. A basal-bolus regimen allows you to closely match how a non-diabetic body would release insulin. It also allows for flexibility, for when you would like to take your meals. Basal-bolus therapy can prevent blood sugar highs and lows, which allows you to feel better throughout the entire day.
There are four major types of human insulin analogs that are available, which are categorized based on how fast they begin working:
There is a fifth type of insulin analog, which is a combination of shorter acting insulin and longer-acting insulin. This type of insulin is called Pre-Mixed insulin, but many refer to it as simply an “insulin mix.” All of these analogs are closely related to naturally occurring insulin in structure and in the ability to control blood sugar levels. Insulin analogs differ from naturally occurring human insulin in their onset of action and in their duration of action.
Rapid-acting insulin analogs are taken as a bolus or mealtime insulin, right before meals, to cover the blood sugar elevation that results from eating. They typically begin to work in about 10 to 30 minutes, with a peak action around 30 minutes after being taken. Their duration of action lasts approximately 3 to 5 hours. The first insulin analog that was developed was rapid-acting Humalog (insulin lispro). Rapid-acting insulins are all rapidly absorbed due to their small structural units that do not combine into larger more complex molecules, as naturally occurring human insulin can. Some examples of rapid-acting insulin analogs are:
Short-acting insulin analogs are also called bolus insulin analogs, which are used to cover your mealtime insulin needs, although they work slightly slower than rapid-acting insulins. They are used for meals eaten within 30 to 60 minutes after being injected. They usually start to work about 30 minutes after subcutaneous injection, with a peak action that occurs in about an hour, and a duration that lasts about 12 hours. Regular insulin also called neutral or soluble insulin is an example of a short-acting insulin analog. An example of a short-acting, brand name insulin is Humulin R.
It is a good idea to practice loading your syringe and using an apple or orange to practice giving injections until you feel you are ready to give your cat or dog an insulin injection. There are many different kinds of syringes, needles, and types of insulin, so make sure you get the right size and type as recommended by your veterinarian. The starting dosage of insulin is typically around 0.25 units per pound, and they are usually given twice a day, with larger dogs needing closer to 0.5 units per pound. The general idea is to start with a low amount of insulin, and then gradually give more if your pet needs it. Injections are usually made near the middle of the back (spine), either behind the shoulders or in front of the pelvis, alternating sides between injections. Using your free hand, pinch a fold of skin and gently insert the needle into the center of the fold. Once the needle is in the skin, gently push the plunger in. Make sure to speak with your vet beforehand about proper injection techniques, and always follow their directions carefully. Injecting your pet may seem difficult at first, but here are some tips to make it easier for you and your pet:
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We ship all major insulin brands; quick, easy, and cheap.
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